Enzymatic Systems

  1. A.A. Caparco*, B.R. Bommarius*, L. Ducrot, J.A. Champion, C. Vergne-Vaxelaire, A.S. Bommarius. “In situ characterization of amine-forming enzymes shows altered oligomeric state.” Protein Science, 2024. DOI 10.1002/pro.5248.
  2. A.A. Caparco*, D.A. Dautel*, J.A. Champion. “Protein Mediated Enzyme Immobilization.” Small, 2022. DOI 10.1002/smll.202106425.
  3. L Ducrot, M. Bennett, A.A. Caparco, J.A. Champion, A.S. Bommarius, A. Zaparucha, G. Grogan, C. Vergne-Vaxelaire. “Biocatalytic Reductive Amination by Native Amine Dehydrogenases to Access Short Chiral Alkyl Amines and Amino Alcohols.” Frontiers in Catalysis, 2021. DOI 10.3389/fctls.2021.781284
  4. R.D. Franklin, J.A. Whitley, A.A. Caparco, J.A. Champion, A.S. Bommarius. “Continuous production of a chiral amine in a packed bed reactor with co-immobilized amine dehydrogenase and formate dehydrogenase.” Chemical Engineering Journal, 2021. DOI 10.1016/j.cej.2020.127065
  5. A.A. Caparco, E. Pelletier, J.L. Petit, A. Jouenne, B.R. Bommarius, V. de Berardinis, A. Zaparucha, J.A. Champion, A.S. Bommarius, C. Vergne-Vaxelaire. “Metagenomic Mining for Amine Dehydrogenase Discovery.” Advanced Synthesis and Catalysis, 2020. DOI 10.1002/adsc.202000094
  6. A.A. Caparco, A. Das, M. Wang, A.S. Bommarius, J.A. Champion. “Tuning the morphology of protein-inorganic calcium-phosphate supraparticles via directed assembly.” Langmuir, 2020. DOI 10.1021/acs.langmuir.0c02735.
  7. A.A. Caparco, B.R. Bommarius, A.S. Bommarius, J.A. Champion. “Protein-Inorganic Calcium-Phosphate Supraparticles as a Robust Platform for Enzyme Co-Immobilization.” Biotechnology and Bioengineering, 2020.  DOI 10.1002/bit.27348
  8. A.A. Caparco, A.S. Bommarius, J.A. Champion. “Effect of Peptide Linker Length and Composition on Immobilization and Catalysis of Leucine Zipper-Enzyme Fusion Proteins.” AIChE Journal, 2018. DOI 10.1002/aic.16150

Viral Nanomaterials

  1. A.A. Caparco, I. Gonzalez-Gamboa, S. Chang-Liao, N.F. Steinmetz. “A plug-and-play strategy for agrochemical delivery using a plant virus nanotechnology.” Journal Nanoparticle Research, 2024. DOI 10.1007/s11051-024-06187-w.
  2. Md. R. Islam, M. Youngblood, H. Kim, I. Gonzalez-Gamboa, A.G. Monroy-Borrego, A.A. Caparco, G.V. Lowry, N.F. Steinmetz, J.P. Giraldo. “DNA Delivery by Virus-Like Nanocarriers in Plant Cells.” Nano Lett., 2024. DOI 10.1021/acs.nanolett.3c04735.
  3. G.V. Lowry, J.P. Giraldo, N.F. Steinmetz,…A.A. Caparco,…J.C. White. “Towards realizing nano-enabled precision delivery in plants.” Nat Nanotechnology, 2024. DOI 10.1038/s41565-024-01667-5.
  4. M.A. Moreno-Gonzalez, Z. Zhao, A.A. Caparco, N.F. Steinmetz. “Combination of cowpea mosaic virus (CPMV) intratumoral therapy and oxaliplatin chemotherapy.” Mater. Adv., 2024. DOI 10.1039/D4MA00427B.
  5. I. Gonzalez-Gamboa, A.A. Caparco, J.M. McCaskill, P.F. Velazquez, S. Hays, Z. Jin, J. Jokerst, J.K. Pokorski, N.F. Steinmetz. “Inter coat protein molecule loading onto TMGMV.” Scientific Reports, 2024. DOI 10.1038/s41598-024-57200-0.
  6. A.A. Caparco, I. Gonzalez-Gamboa, S. Hays, J.K. Pokorski, N.F. Steinmetz. “Delivery of Nematicides Using TMGMV-Derived Spherical Nanoparticles.” Nano Lett, 2023. DOI 10.1021/acs.nanolett.3c01684.
  7. A.A. Caparco*, U.P. Venkateswaran*, I. Gonzalez-Gamboa, R. Caballero, N.F. Steinmetz. “Plant Viral Nanocarrier Soil Mobility as a Function of Soil Type and Nanoparticle Properties.” ACS Agricultural Science and Technology, 2023. DOI 10.1021/acsagscitech.3c00074.
  8. A.A. Caparco*, I. Gonzalez-Gamboa*, J.M. McCaskill, N.F. Steinmetz. “Bioconjugation strategies for Tobacco mild green mosaic virus.” ChemBioChem, 2022. DOI 10.1002/cbic.202200323.

Other Works

  1.  E. Davis, A.A. Caparco, N.F. Steinmetz, P.K. Pokorski. “Study of uricase-polynorbornene conjugates derived from grafting-from ring-opening metathesis polymerization.” J. Mat Chem B, 2024. DOI 10.1039/D3TB02726K.
  2. E. Davis, A.A. Caparco, N.F. Steinmetz, P.K. Pokorski. “Poly(Oxanorbornene)-Protein Conjugates Prepared by Grafting-to ROMP as Alternatives for PEG.” Macromolecular Bioscience, 2023. DOI 10.1002/mabi.202300255.
  3. D.C. Church*, E. Davis*, A.A. Caparco, L. Takiguchi, Y.H. Chung, N.F. Steinmetz, J.K. Pokorski. “Polynorbornene Based Bioconjugates by Aqueous Grafting-from Ring Opening Metathesis Polymerization Reduce Protein Immunogenicity.” Cell Rep. Phys. Sci., 2022. DOI 10.1016/j.xcrp.2022.101067.

Professor Caparco’s Google Scholar